2025
- Swingle, K. L., Hamilton, A. G., Safford, H. C., Geisler, H. C., Thatte, A. S., Palanki, R., Murray, A. M., Han, E. L., Mukalel, A. J., Han, X., Palanki, R., Joseph, R. A., Ghalsasi, A. A., Alameh, M.-G., Weissman, D., Mitchell, M.J. (2025). Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature.
- Safford, H.C., Shuler, C. F., Geisler, H. C., Thatte, A. S., Swingle, K. L., Han, E. H., Murray, A. M., Hamilton, A. G., Yamagata, H., Mitchell, M. J. (2025). Probing the role of lipid nanoparticle elasticity on mRNA delivery to the placenta. Nano Letters.
- Xue, L., Swingle, K. L., Mitchell, M. J. (2025). Small structural changes in siloxane-based lipidoids improve tissue-specific mRNA delivery. Nature Nanotechnology.
- Xue, L.*, Zhao, G.*, Gong, N.*, Han, X., Shepherd, S. J., Xiong, X. Xiao, Z., Palanki, R., Xu, J., Swingle, K. L., Warzecha, C. C., El-Mayta, R., Chowdhary, V., Yoon, I.-C., Xu, J., Cui, J., Shi, Y., Alameh, M.-G., Wang, K., Wang, L., Pochan, D. J., Weissman, D., Vaughan, A. E., Wilson, J. M., Mitchell, M. J. (2025). Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nature Nanotechnology.
2024
- Han, E. L., Tang, S., Kim, D., Murray, A. M., Swingle, K. L., Hamilton, A. G., Mrksich, K., Padilla M. S., Palanki, R., Li, J. J., Mitchell, M. J. (2024). Peptide-functionalized lipid nanoparticles for targeted systemic mRNA delivery to the brain. Nano Letters.
- Han, X., Alameh, M.-G., Xu, Y., Palanki, R., El-Mayta, R., Dwivedi, G., Swingle, K. L., Xu, J., Gong, N., Xue, L., Shi, Q., Yoon, I.-C., Warzecha, C. C., Wilson, J. M., Weissman, D., Mitchell, M. J. (2024). Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nature Biomedical Engineering.
- Swingle, K. L., Hamilton, A. G., Mitchell, M. J. (2024). Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Placenta.
- Palanki, R.*, Riley, J. S.*, Bose, S. K., Luks, V., Dave, A., Kus, N., White, B. M., Ricciardi, A. S., Swingle, K. L., Xue, L., Sung, D., Thatte, A. S., Safford, H. C., Chaluvadi, V. S., Carpenter, M., Han, E. L., Maganti, R., Hamilton, A. G., Mrksich, K., Billingsley, M. M., Zoltick, P., Alameh, M.-G., Weissman, D., Mitchell, M. J., Peranteau, W. H. (2024). In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proceedings of the National Academy of Sciences.
- Palanki, R., Han, E. L., Murray, A. M., Maganti, R., Tang, S., Swingle, K. L., Kim, D., Yamagata, H., Safford, H. C., Mrksich, K., H. C., Peranteau, W. H., Mitchell, M. J. (2024). Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab on a Chip.
- Geisler, H. C., Ghalsasi, A. A., Safford, H. C., Swingle, K. L., Thatte, A. S., Mukalel, A. J., Gong, N., Hamilton, A. G., Han, E. L., Nachod, B. E., Padilla, M. S., Mitchell, M. J. (2024). EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. Journal of Controlled Release.
- Hamilton, A. G., Swingle, K. L., Thatte, A. S., Mukalel, A. J., Safford, H. C., Billingsley, M. M., El-Mayta, R., Han, X., Nachod, B. E., Joseph, R. A., Metzloff, A. E., Mitchell, M. J. (2024). High-throughput in vivo screening identifies differential influences on mRNA LNP immune cell delivery by administration route. ACS Nano.
- Billingsley, M. M., Gong, N., Mukalel, A. J., Thatte, A. S., El-Mayta, R., Patel, S. K., Metzloff, A. E., Swingle, K. L., Han, X., Xue, L., Hamilton, A. G., Safford, H. C., Alameh, M.-G., Papp, T., Parhiz, H., Weissman, D., Mitchell, M. J. (2024). In vivo CAR T cell engineering via targeted lipid nanoparticles with extrahepatic tropism. Small.
2023
- Thatte, A. S., Hamilton, A. G., Nachod, B. E., Mukalel, A. J., Billingsley, M. M., Palanki, R., Swingle, K. L., Mitchell, M. J. (2023). mRNA lipid nanoparticles for ex vivo engineering of immunosuppressive T cells for autoimmunity therapies. Nano Letters.
- Hamilton, A. G., Swingle, K. L., Joseph, R. A., Mai, D., Gong, N., Billingsley, M. M., Alameh, M.-G., Weissman, D., Sheppard, N. C., June, C. H., Mitchell, M. J. (2023). Ionizable lipid nanoparticles with integrated immune checkpoint inhibition for mRNA CAR T cell therapy. Advanced Healthcare Materials.
- Safford, H. C., Swingle, K. L., Geisler, H. C., Hamilton, A. G., Thatte, A. S., Ghalsasi, A. A., Billingsley, M. M., Alameh, M.-G., Weissman, D., Mitchell, M. J. (2023). Orthogonal design of experiments for engineering of lipid nanoparticles for mRNA delivery to the placenta. Small.
- Palanki, R.*, Bose, S. K.*, Dave, A., White, B. M., Berkowitz, C., Luks, V., Yaqoob, F., Han, E., Swingle, K. L., Menon, P., Hodgson, E., Biswas, A., Billingsley, M. M., Li, L., Yiping, F., Carpenter, M., Trokhan, A., Yeo, J., Johana, N., Wan, Wan, T. Y., Alameh, M.-G., Zoltick, P., Bennett, F., Storm, P., Jain, R., Chan, J., Weissman, D., Mitchell, M. J., Peranteau, W. H. (2023). Ionizable lipid nanoparticles for therapeutic base editing of congenital brain disease. ACS Nano.
- Swingle, K. L., Ricciardi, A. S., Peranteau, W. H., & Mitchell, M. J. (2023). Delivery technologies for women’s health applications. Nature Reviews Bioengineering.
- Hamilton, A. G.*, Swingle, K. L.*, Mitchell, M. J. (2023). Biotechnology: overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS Biology.
- Swingle, K. L., Safford, H. C., Geisler, H. C., Hamilton, A. G., Thatte, A. S., Billingsley, M. M., Joseph, R. A., Mrksich, K., Padilla, M. S., Ghalsasi, A. A., Alameh, M.-G., Weissman, D., & Mitchell, M. J. (2023). Ionizable lipid nanoparticles for in vivo mRNA delivery to the placenta during pregnancy. Journal of the American Chemical Society.
- Bashiri, G., Padilla, M. S., Swingle, K. L., Shepherd, S. J., Mitchell, M. J., Wang, K. (2023). Nanoparticle protein corona: from structure and function to therapeutic targeting. Lab on a Chip.
2022
- Palanki, R.*, Swingle, K. L.*, Mitchell, M. J. (2022). A (controlled) spill of IL2 for localized treatment of mesothelioma. Clinical Cancer Research.
- Patel, S. K., Billingsley, M. M., Frazee, C., Han, X., Swingle, K. L., Qin, J., Alameh, M.-G., Wang, K., Weissman, D., Mitchell, M. J. (2022). Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells.
- Sekhon, U. D. S., Swingle, K.L., Girish, A., Luc, N., de la Fuente, M., Alvikas, J., Haldeman, S., Hassoune, A., Shah, K., Kim, Y., Eppell, S., Capadona, J., Shoffstall, A., Neal, M. D., Li, W., Nieman, M., Sen Gupta, A. (2022). Platelet-mimicking procoagulant nanoparticles augment hemostasis in animal models of bleeding. Science Translational Medicine.
- Qin, J., Xue, L., Gong, N., Zhang, H., Shepherd, S. J., Haley, R.M., Swingle, K.L., Mitchell, M. J. (2022). RGD peptide-based lipids for targeted mRNA delivery and gene editing applications. RSC Advances.
- Swingle, K. L., Billingsley, M. M., Bose, S. K., White, B., Palanki, R., Dave, A., Patel, S. K., Gong, N., Hamilton, A. G., Alameh, M.-G., Weissman, D., Peranteau, W. H., Mitchell, M. J. (2022). Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. Journal of Controlled Release.
- Han, X., Zhang, H., Butowska, K., Swingle, K. L., Alameh, M.-G., Weissman, D., Mitchell, M. J. (2021). An ionizable lipid toolbox for RNA delivery. Nature Communications.
- Billingsley, M. M., Hamilton, A. G., Mai, D., Patel, S. K., Swingle, K. L., Sheppard, N. C., June, C. H., Mitchell, M. J. (2022). Orthogonal design of experiments for optimization of lipid nanoparticles for mRNA engineering of CAR T cells. Nano Letters.
2021
- Swingle, K. L.*, Hamilton, A. G.*, Mitchell, M. J. (2021). Lipid nanoparticle-mediated delivery of mRNA therapeutics and vaccines. Trends in Molecular Medicine.